Development of an aptamer that binds to Dvl1 to which CXXC5 binds among Wnt pathway components (WD (WntDvl1)-Aptamer) By binding WD-Aptamer to the CXXC5 binding site of the Dvl1 protein, it prevents the binding of Dvl1 and CXXC5 to decrease cell proliferation
Confirmation of binding of Dvl1 and WD-Aptamer (shows strong binding at nM level.)
Hair re-growth effect confirmed through in vivo experiment (confirmed better effect than control group Minoxidil)
WD Aptamer의 DVL_PDZ domain Binding 확인
The result of FPLC measurement shows the result of about 20kDa, which is the peak size when Dvl1_PDZ and WD Aptamer are bound at 1:1 ratio.
The hair growth effects of the animal model
As a result of the mouse experiment compared to minoxidil,
15 days later than the control that did not treat anything
A significant hair growth effect was confirmed in the group treated with WD-Aptamer.
It also shows a noticeable difference in effect when compared to the hair growth agent Minoxidil.