WD Aptamer

A new approach for hair loss therapeutics

Normalization of Wnt signaling pathway

CXXC5-Dvl, which binds to WntDvl1(WD) aptamer promotes hair follicle generation and formation process through restoration of Wnt/ beta catechin signal, thereby treating hair loss symptoms in which hair follicles are damaged.

Target pathway : Wnt/β-catenin signaling
Target protein : Dvl1 protein
Aptamer design : WntDvl1(WD) aptamer which conjoin with PDZ domain (CXXC5 binding site) which is Dvl1 protein