As the paradigm of healthcare shifts from “treatment” to “prevention” of diseases, early diagnosis has become crucial. We have been researching and developing skin patches that detect Parkinson’s disease, Alzheimer’s disease, and various other diseases by capturing target biomarkers.
aptamer coated microneedle skin patch
Aptamer is capable of simultaneously diagnosing various diseases. It can be produced in a short time at low cost. Because aptamer is produced by chemical synthesis, there is less variation between batches, and the chemical modification can easily be conducted. It can be stored for a long time with high thermostability.
Applying various methods including the ELISA, we have developed aptamers that bind to specific HRP2 proteins that are overexpressed in patients with malaria.
We are in process of developing aptamers targeting Tau and Amyloid beta (Aβ).
Lewy body is an abnormal inclusion body which causes Parkinson’s Disease. Alphasynuclein is a major component of Lewy body and is presented as a monomer in normal conditions, but toxic amyloid oligomers are generated in a pathological environment. We are developing aptamers that capture these oligomers.